Do any of these sides have an edge when looking into Week 6 NFL bets? All of the Week 6 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 6 NFL picks now. The Giants will be without Daniel Jones (neck) and will turn to Tyrod Taylor to make his first start since Week 13 of the 2021 NFL season. The Broncos already lost and failed to cover the spread this week, but can the Giants or Panthers break their streak and overcome the Week 6 NFL odds? The Giants are 15-point underdogs against the Bills in the latest NFL spreads, while the Panthers are 14-point underdogs against the Dolphins. However, there are three franchises winless against the spread this season: the Giants, Broncos and Panthers. The Eagles and 49ers are the final undefeated teams entering the Week 6 NFL schedule, but no team is undefeated against the spread after five weeks.
